Locked Nucleic Acids (LNA) Knowledge Center

Detect and discriminate short or closely related sequences with ease
LNA oligos exhibit unprecedented thermal stability when hybridized to their complement. This much higher affinity – compared to traditional DNA or RNA oligos – helps overcome the difficulties of studying very short sequences. LNA oligos have greatly improved, and in many cases enabled, specific and sensitive detection of non-coding RNA and other small RNA molecules. Beyond RNA, these powerful tools are ideal for detecting low-abundance, short or highly similar targets in many other research applications. QIAGEN and Exiqon have merged our expertise to provide a comprehensive portfolio of LNA-enhanced research tools. Read on and learn how you can use these to gain more insights from your experiments.